General Information:

Id: 119 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
NSC34 cells, expressing SOD1(G93A) or SOD1(G85R)
BTO:0004488 NSC-34 cell; BTO:0000312 motoneuron
article
Reference: Hetz C et al.(2009) XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy Genes Dev. 23: 2294-2306 [PMID: 19762508]

Interaction Information:

Comment Consistent with a decrease in the levels of mutant SOD1 misfolding, shXBP-1 (XBP-1 knockdown) cells displayed increased survival after SOD1(G85R) expression as measured by monitoring mitochondrial activity with the MTT assay.
Formal Description
Interaction-ID: 5017

gene/protein

XBP1

increases_activity of

process

neuron death