General Information:

Id: 11,934 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Mammalia
article
Reference: Kostenis E et al.(2005) G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor Circulation 111: 1806-1813 [PMID: 15809376]

Interaction Information:

Comment The G-protein-coupled receptor Mas, encoded by the Mas proto-oncogene, has been identified as an endogenous receptor for the heptapeptide angiotensin-(1-7); however, the receptor is also suggested to be involved in actions of angiotensin II. The study tested whether this could be mediated indirectly through an interaction with the angiotensin II type 1 receptor, AT1. In transfected mammalian cells, Mas was not activated by angiotensin II; however, AT1 receptor-mediated, angiotensin II-induced production of inositol phosphates and mobilization of intracellular Ca2+ was diminished by 50% after coexpression of Mas, despite a concomitant increase in angiotensin II binding capacity. Mas and the AT1 receptor formed a constitutive hetero-oligomeric complex that was unaffected by the presence of agonists or antagonists of the 2 receptors. In vivo, Mas acts as an antagonist of the AT1 receptor; mice lacking the Mas gene show enhanced angiotensin II-mediated vasoconstriction in mesenteric microvessels. These results demonstrate that Mas can hetero-oligomerize with the AT1 receptor and by so doing inhibit the actions of angiotensin II.
Formal Description
Interaction-ID: 117335

complex/PPI

AGTR1-MAS1 complex

decreases_activity of

gene/protein

AGTR1

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