General Information:

Id: 11,926 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Rattus norvegicus
article
Reference: Ahmad S et al.(2016) Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme Biochem. Biophys. Res. Commun. 478: 559-564 [PMID: 27465904]

Interaction Information:

Comment Overall the findings suggest that Ang-(1-12), not Ang I, is the better substrate for Ang II formation by chymase in adult rats. In addition, this confirms the previous observation that chymase (rather than ACE) is the main hydrolyzing enzyme responsible for Ang II generation from Ang-(1-12) in the adult rat heart.
Formal Description
Interaction-ID: 117293

gene/protein

CMA1

decreases_quantity of

gene/protein

Angiotensin (1-12)

in heart
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