General Information:

Id: 11,924 (click here to show other Interactions for entry)
Diseases: Endocrine
Mus musculus
Reference: Patel VB et al.(2014) Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS J. Mol. Cell. Cardiol. 66: 167-176 [PMID: 24332999]

Interaction Information:

Comment Ang II infusion in wild-type mice resulted in substantial decrease in myocardial ACE2 protein levels and activity with corresponding increase in plasma ACE2 activity, prevented by AT1R blockade. Ang II resulted in AT1R-mediated increase in myocardial TACE expression and activity, and membrane translocation of TACE.
Formal Description
Interaction-ID: 117260



increases_activity of



in myocardium
Drugbank entries Show/Hide entries for AGTR1 or ADAM17