General Information:

Id: 11,921 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Mus musculus
Reference: Zini S et al.(1996) Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release Proc. Natl. Acad. Sci. U.S.A. 93 [PMID: 8876246]

Interaction Information:

Comment Mice received Ang II intracerebroventricularly in the presence or absence of the aminopeptidase A (APA) inhibitor, EC33 (3-amino-4-thio-butyl sulfonate) or of the aminopeptidase N (APN) inhibitor, EC27 (2-amino-pentan-1,5-dithiol). Ang II and Ang III levels were evaluated from hypothalamus homogenates by HPLC. EC33 increased the half-life of Ang II 2.6-fold and completely blocked the formation of Ang III, whereas EC27 increased the half-life of Ang III 2.3-fold. These results demonstrate that APA and APN are involved in vivo in the metabolism of brain Ang II and Ang III, respectively.
Formal Description
Interaction-ID: 119255


Angiotensin II

increases_quantity of


Angiotensin III

in hypothalamus