General Information:

Id: 11,919 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Rattus norvegicus
article
Reference: Mendoza-Torres E et al.(2018) Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT2R and Akt-dependent mechanism Pharmacol. Res. 135: 112-121 [PMID: 30048754]

Interaction Information:

Comment Systemic delivery of angiotensin-(1-9) significantly decreased cell death and improved left ventricular recovery after in vivo myocardial infarction. In vitro, angiotensin-(1-9) decreased cell death in isolated neonatal rat ventricular cardiomyocytes subjected to simulated ischemia/reperfusion. The cardioprotective effects of angiotensin-(1-9) were blocked by PD123319 (AT2R antagonist) and Akt inhibitor but not by A779 (Mas antagonist). Angiotensin-(1-9) limits reperfusion-induced cell death by an AT2R- and Akt-dependent mechanism.
Formal Description
Interaction-ID: 117249

gene/protein

Angiotensin (1-9)

increases_activity of

gene/protein

AGTR2

in cardiomyocytes
Drugbank entries Show/Hide entries for AGTR2