General Information:

Id: 11,918 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Rattus norvegicus
Reference: Yu L et al.(2016) Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor Peptides 86: 33-41 [PMID: 27660028]

Interaction Information:

Comment Angiotensin-(1-5) [Ang-(1-5)], which is a metabolite of Angiotensin-(1-7) [Ang-(1-7)] catalyzed by angiotensin-converting enzyme (ACE), is a pentapeptide of the renin-angiotensin system (RAS). It has been reported that Ang-(1-7) and Ang-(1-9) stimulate the secretion of atrial natriuretic peptide (ANP) via Mas receptor (Mas R) and Ang II type 2 receptor (AT2R), respectively. The effect of Ang-(1-5) on ANP secretion was investigated using isolated perfused beating rat atria. Ang-(1-5) stimulated high pacing frequency-induced ANP secretion in a dose-dependent manner. Ang-(1-5)-induced ANP secretion was attenuated by the pretreatment with an antagonist of Mas R (A-779) but not by an antagonist of AT1R (losartan) or AT2R (PD123,319).
Formal Description
Interaction-ID: 117242


Angiotensin (1-5)

increases_activity of



in atrium