General Information:

Id: 11,902
Diseases: Neurological
Mus musculus
article
Reference: Xu J et al.(2017) Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension Circ. Res. 121: 43-55 [PMID: 28512108]

Interaction Information:

Comment Neuronal AT1aR (AGTR1) is required for ADAM17 activation during DOCA-salt hypertension, but constitutive ADAM17 enzymatic activity does not rely on the presence of neuronal AT1aR (AGTR1).
Formal Description
Interaction-ID: 117160

gene/protein

AGTR1

increases_activity of

gene/protein

ADAM17

in the hypothalamus ; during DOCA-salt hypertension
Drugbank entries Show/Hide entries for AGTR1 or ADAM17