General Information:

Id: 1,189 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Kim HJ et al.(2004) Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo Diabetes 53: 1060-1067 [PMID: 15047622]

Interaction Information:

Comment IL-6 decreased skeletal muscle insulin action and signaling in vivo.
Formal Description
Interaction-ID: 7926

gene/protein

IL6

decreases_activity of

in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment IL-6 treatment significantly reduced insulin-stimulated IRS-1-associated PI 3-kinase activity, a key intracellular mediator of insulin signaling in skeletal muscle.
Formal Description
Interaction-ID: 7927

gene/protein

IL6

decreases_activity of

complex/PPI

Phosphatidylinositol 3-kinase

in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment IL-6 treatment increased tyrosine phosphorylation of STAT3 in skeletal muscle, indicating that the effect of IL-6 on skeletal muscle was mediated by IL-6-induced activation of the gp130 complex.
Formal Description
Interaction-ID: 7928

gene/protein

IL6

increases_phosphorylation of

gene/protein

STAT3

in skeletal muscle; at Tyr residues of STAT3
Drugbank entries Show/Hide entries for IL6
Comment IL-6 induced hepatic insulin resistance in vivo.
Formal Description
Interaction-ID: 7929

gene/protein

IL6

increases_activity of

disease

Insulin resistance

in liver
Drugbank entries Show/Hide entries for IL6