General Information:

Id: 11,899 (click here to show other Interactions for entry)
Diseases: Neurological
SARS-CoV infection
Homo sapiens
27 patients with neurogenic hypertension
article
Reference: Xu J et al.(2017) Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension Circ. Res. 121: 43-55 [PMID: 28512108]

Interaction Information:

Comment Angiotensin II type 1 receptors promote ADAM17-mediated ACE2 shedding in the brain of hypertensive patients, leading to a loss in compensatory activity during neurogenic hypertension.
Formal Description
Interaction-ID: 117239

gene/protein

AGTR1

increases_activity of

gene/protein

ADAM17

in cerebrospinal fluid; during the development of DOCA-salt hypertension
Drugbank entries Show/Hide entries for AGTR1 or ADAM17