General Information:

Id: 11,899 (click here to show other Interactions for entry)
Diseases: Neurological
SARS-CoV infection
Homo sapiens
27 patients with neurogenic hypertension
article
Reference: Xu J et al.(2017) Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension Circ. Res. 121: 43-55 [PMID: 28512108]

Interaction Information:

Comment Soluble ACE2 is the main enzyme converting Ang II into Ang-(1–7) in human cerebrospinal fluid.
Formal Description
Interaction-ID: 117136

gene/protein

ACE2, soluble

increases_quantity of

gene/protein

Angiotensin (1-7)

in cerebrospinal fluid
Comment Soluble ACE2 activity was more than doubled in the cerebrospinal fluid of individuals with uncontrolled hypertension. This suggests that ADAM17-mediated ACE2 shedding is taking place in the CNS during human hypertension. The increased level of TNFalpha in those cerebrospinal fluid samples confirmed that ADAM17 was upregulated in the brain of hypertensive patients.
Formal Description
Interaction-ID: 117156

phenotype

hypertension

increases_activity of

gene/protein

ACE2, soluble

in cerebrospinal fluid
Comment Soluble ACE2 is the main enzyme converting Ang II into Ang-(1–7) in human cerebrospinal fluid.
Formal Description
Interaction-ID: 117157

gene/protein

ACE2, soluble

decreases_quantity of

gene/protein

Angiotensin II

in cerebrospinal fluid
Comment Angiotensin II type 1 receptors promote ADAM17-mediated ACE2 shedding in the brain of hypertensive patients, leading to a loss in compensatory activity during neurogenic hypertension.
Formal Description
Interaction-ID: 117239

gene/protein

AGTR1

increases_activity of

gene/protein

ADAM17

in cerebrospinal fluid; during the development of DOCA-salt hypertension
Drugbank entries Show/Hide entries for AGTR1 or ADAM17