General Information:

Id: 11,899 (click here to show other Interactions for entry)
Diseases: Neurological
SARS-CoV infection
Homo sapiens
27 patients with neurogenic hypertension
article
Reference: Xu J et al.(2017) Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension Circ. Res. 121: 43-55 [PMID: 28512108]

Interaction Information:

Comment Soluble ACE2 activity was more than doubled in the cerebrospinal fluid of individuals with uncontrolled hypertension. This suggests that ADAM17-mediated ACE2 shedding is taking place in the CNS during human hypertension. The increased level of TNFalpha in those cerebrospinal fluid samples confirmed that ADAM17 was upregulated in the brain of hypertensive patients.
Formal Description
Interaction-ID: 117156

phenotype

hypertension

increases_activity of

gene/protein

ACE2, soluble

in cerebrospinal fluid