General Information:

Id: 1,184 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Chronic granulomatous disease
Mammalia
review
Reference: Wilkinson BL and Landreth GE(2006) The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimers disease J Neuroinflammation 3: 30 [PMID: 17094809]

Interaction Information:

Comment The source of fibrillar beta-amyloid induced reactive oxygen species is primarily the microglial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
Formal Description
Interaction-ID: 7859

complex/PPI

Amyloid beta peptide (fibrillar)

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment The source of fibrillar beta-amyloid induced reactive oxygen species is primarily the microglial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
Formal Description
Interaction-ID: 7860

complex/PPI

NADPH oxidase complex

increases_quantity of

drug/chemical compound

Reactive oxygen species

in microglia; via amyloid beta peptide
Comment Confirmation of NADPH oxidase participation in Abeta-induced ROS production has been obtained utilizing cells obtained from patients with the rare recessive genetic disorder, chronic granulomatous disease (CGD). This disease is characterized by a mutation in the genes that encode one of the essential subunits of the NADPH oxidase: p22phox, p47phox, p67phox or gp91phox. These defects render the cells unable to generate H2 O2 in response to any agonist of the oxidase. Subsequent studies have substantiated that the NADPH oxidase is essential for Abeta-induced ROS production.
Formal Description
Interaction-ID: 8347

complex/PPI

NADPH oxidase complex

affects_quantity of

drug/chemical compound

Reactive oxygen species

if ROS production is Abeta-induced
Comment The source of fibrillar beta-amyloid induced reactive oxygen species is primarily the microglial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
Formal Description
Interaction-ID: 80164

increases_quantity of

drug/chemical compound

Reactive oxygen species