General Information:

Id: 1,184 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Chronic granulomatous disease
Mammalia
review
Reference: Wilkinson BL and Landreth GE(2006) The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimers disease J Neuroinflammation 3: 30 [PMID: 17094809]

Interaction Information:

Comment Senile plaques of AD patients are surrounded by activated microglia, which are largely responsible for the proinflammatory environment within the diseased brain.
Formal Description
Interaction-ID: 7845

process

microglial cell activation

increases_activity of

process

inflammatory response

within the diseased brain
Comment In response to contact with fibrillar beta-amyloid, microglia secrete a diverse array of proinflammatory molecules.
Formal Description
Interaction-ID: 7858

complex/PPI

Amyloid beta peptide (fibrillar)

increases_activity of

process

inflammatory response