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	Field	Term

General Information:

Id:	11,842
Diseases:	Endocrine
Organism:	Mus musculus
Gender:	male
Tissue/Cell line:	kidney
Publication type:	article
Reference:	Grobe N et al.(2013) Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry Am. J. Physiol. 304: C945-C953 [PMID: 23392115]

Interaction Information:

Comment	ACE2 metabolizes ANG II to Ang 1-7 in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.
Formal Description Interaction-ID: 116926	gene/protein PRCP decreases_quantity of gene/protein Angiotensin II in kidney ; at acidic pH

Comment	ACE2 metabolizes ANG II to Ang 1-7 in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.
Formal Description Interaction-ID: 116927	gene/protein PRCP increases_quantity of gene/protein Angiotensin (1-7) in kidney ; at acidic pH

Comment	ACE2 metabolizes ANG II to Ang 1-7 in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.
Formal Description Interaction-ID: 116928	gene/protein ACE2 increases_quantity of gene/protein Angiotensin (1-7) in kidney ; at neutral to basic pH
Drugbank entries	Show/Hide entries for ACE2
Drugbank DB00691	Moexipril inhibitor ACE2
Drugbank DB00722	Lisinopril inhibitor ACE2

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