General Information:

Id: 11,837
Diseases: Endocrine
Homo sapiens
CHO cells transfected with human genes
article
Reference: Donoghue M et al.(2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Circ. Res. 87: E1-E9 [PMID: 10969042]

Interaction Information:

Comment ACE2 and ACE catalytic activity has been analyzed in CHO cells expressing human ACE2. ACE converted the decapeptide Ang I to Ang II. ACE2, in contrast, converted Ang I to the nonapeptide Ang1-9.
Formal Description
Interaction-ID: 116863

gene/protein

ACE

decreases_quantity of

gene/protein

Angiotensin I

Drugbank entries Show/Hide entries for ACE
Comment ACE2 and ACE catalytic activity has been analyzed in CHO cells expressing human ACE2. ACE converted the decapeptide Ang I to Ang II. ACE2, in contrast, converted Ang I to the nonapeptide Ang1-9.
Formal Description
Interaction-ID: 116866

gene/protein

ACE

increases_quantity of

gene/protein

Angiotensin II

Drugbank entries Show/Hide entries for ACE
Comment ACE2 and ACE catalytic activity has been analyzed in CHO cells expressing human ACE2. ACE converted the decapeptide Ang I to Ang II. ACE2, in contrast, converted Ang I to the nonapeptide Ang1-9.
Formal Description
Interaction-ID: 116867

gene/protein

Angiotensin I

increases_quantity of

gene/protein

Angiotensin II

via the catalytic activity of ACE
Comment ACE2 and ACE catalytic activity has been analyzed in CHO cells expressing human ACE2. ACE converted the decapeptide Ang I to Ang II. ACE2, in contrast, converted Ang I to the nonapeptide Ang1-9.
Formal Description
Interaction-ID: 116868

gene/protein

Angiotensin I

increases_quantity of

gene/protein

Angiotensin (1-9)

via the catalytic activity of ACE2
Comment ACE2 and ACE catalytic activity has been analyzed in CHO cells expressing human ACE2. ACE converted the decapeptide Ang I to Ang II. ACE2, in contrast, converted Ang I to the nonapeptide Ang1-9.
Formal Description
Interaction-ID: 116869

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin I

Drugbank entries Show/Hide entries for ACE2
Comment ACE2 and ACE catalytic activity has been analyzed in CHO cells expressing human ACE2. ACE converted the decapeptide Ang I to Ang II. ACE2, in contrast, converted Ang I to the nonapeptide Ang1-9.
Formal Description
Interaction-ID: 116870

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-9)

Drugbank entries Show/Hide entries for ACE2
Comment Incubation of Ang1-9 with ACE in vitro generated Ang1-7 and Ang1-5, apparently by sequential cleavage of C-terminal dipeptides.
Formal Description
Interaction-ID: 116873

gene/protein

ACE

decreases_quantity of

gene/protein

Angiotensin (1-9)

Drugbank entries Show/Hide entries for ACE
Comment Incubation of Ang1-9 with ACE in vitro generated Ang1-7 and Ang1-5, apparently by sequential cleavage of C-terminal dipeptides.
Formal Description
Interaction-ID: 116874

gene/protein

ACE

increases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for ACE
Comment Incubation of Ang1-9 with ACE in vitro generated Ang1-7 and Ang1-5, apparently by sequential cleavage of C-terminal dipeptides.
Formal Description
Interaction-ID: 116875

gene/protein

ACE

increases_quantity of

gene/protein

Angiotensin (1-5)

Drugbank entries Show/Hide entries for ACE
Comment Incubation of Ang1-9 with ACE in vitro generated Ang1-7 and Ang1-5, apparently by sequential cleavage of C-terminal dipeptides.
Formal Description
Interaction-ID: 116876

gene/protein

ACE

decreases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for ACE
Comment Incubation of Ang1-9 with ACE in vitro generated Ang1-7 and Ang1-5, apparently by sequential cleavage of C-terminal dipeptides.
Formal Description
Interaction-ID: 116883

gene/protein

Angiotensin (1-7)

increases_quantity of

gene/protein

Angiotensin (1-5)

Comment Incubation of Ang1-9 with ACE in vitro generated Ang1-7 and Ang1-5, apparently by sequential cleavage of C-terminal dipeptides.
Formal Description
Interaction-ID: 116884

gene/protein

Angiotensin (1-9)

increases_quantity of

gene/protein

Angiotensin (1-7)