General Information:

Id: 11,830 (click here to show other Interactions for entry)
Diseases: SARS-CoV infection
Mus musculus
article
Reference: Kuba K et al.(2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Nat. Med. 11: 875-879 [PMID: 16007097]

Interaction Information:

Comment ACE2 functions as a carboxypeptidase, cleaving a single residue from angiotensin I (AngI), generating Ang1-9, and a single residue from angiotensin II (AngII) to generate Ang1-7. The ACE2 homologue ACE, by contrast, cleaves the decapeptide AngI into the octapeptide AngII. Thus, ACE2 counterbalances the function of ACE and negatively regulates AngII production. To test whether Spike-Fc injections indeed affect the function of the renin-angiotensin system, AngII levels in the lungs of acid- and Spike-Fc–treated mice were analyzed. Acid aspiration increased AngII levels in the lungs of wild-type mice. Notably, the authors observed a further, significant increase in AngII levels in the lung tissue of mice treated with Spike-Fc.
Formal Description
Interaction-ID: 116886

environment

SARS-CoV S protein

increases_quantity of

gene/protein

Angiotensin II

in the lung