General Information:

Id: 1,182 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0000099 astrocyte
Reference: Cassina P et al.(2002) Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis J. Neurosci. Res. 67: 21-29 [PMID: 11754077]

Interaction Information:

Comment The concentration of nitrite and nitrate accumulating in the culture media increased three- to fourfold following exposure to either peroxynitrite or LPS compared with control cultures. Nitrite and nitrate synthesis was substantially blocked by the NOS inhibitor L-NAME, suggesting that iNOS is actively producing NO.
Formal Description
Interaction-ID: 7837



increases_quantity of

drug/chemical compound


in primary astrocyte monolayers
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