General Information:

Id: 1,179 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Becerril S et al.(2010) Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function PLoS ONE 5 [PMID: 20532036]

Interaction Information:

Comment iNOS deletion enhanced the expression of mitochondria-related proteins, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (Pgc-1alpha), sirtuin-1 (Sirt-1) and sirtuin-3 (Sirt-3). Accordingly, mitochondrial uncoupling proteins 1 and 3 (Ucp-1 and Ucp-3) were upregulated in brown adipose tissue (BAT) of DBKO mice as compared to ob/ob rodents.
Formal Description
Interaction-ID: 7814

gene/protein

NOS2

affects_expression of

gene/protein

PPARGC1A

Drugbank entries Show/Hide entries for NOS2