General Information:

Id: 11,748 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
review
Reference: Sriram K and Insel PAA hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance [PMID: 32333398]

Interaction Information:

Comment Both, ANG II and ANG IV act primarily via the angiotensin II receptor type 1 (AGTR1).
Formal Description
Interaction-ID: 116372

gene/protein

Angiotensin IV

increases_activity of

gene/protein

AGTR1

Drugbank entries Show/Hide entries for AGTR1
Comment ANG (1-7) acts primarily via the G protein-coupled receptor MAS1, and forms ANG (1-5), which signals via MRGPRD. ANG (1-7) can also act via the AGTR2 receptor but with much lower affinity than ANG II.
Formal Description
Interaction-ID: 116378

gene/protein

Angiotensin (1-7)

increases_activity of

gene/protein

AGTR2

but with lower affinity than ANG II
Drugbank entries Show/Hide entries for AGTR2
Comment ANG (1-7) acts primarily via the G protein-coupled receptor MAS1, and forms ANG (1-5), which signals via MRGPRD. ANG (1-7) can also act via the AGTR2 receptor but with much lower affinity than ANG II.
Formal Description
Interaction-ID: 116379

gene/protein

Angiotensin II

increases_activity of

gene/protein

AGTR2

with higher affinity than Angiotensin (1-7)
Drugbank entries Show/Hide entries for AGTR2
Comment ACE2, in particular its catalytic ectodomain, can be shed from cells into the circulation as soluble ACE2, an action mediated by the metalloprotease ADAM17, an activator of Notch pathway.
Formal Description
Interaction-ID: 116392

gene/protein

ADAM17

increases_quantity of

gene/protein

ACE2, soluble

via proteolysis
Drugbank entries Show/Hide entries for ADAM17
Comment ANG II is cleaved by multiple enzymes, e.g. prolyl endopeptidase (PREP), but most importantly ACE2, to form ANG (1-7). ANG II also forms ANG IV via the action of aminopeptidases.
Formal Description
Interaction-ID: 116398

gene/protein

PREP

increases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for PREP