General Information:

Id: 1,169 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Down syndrome - [OMIM]
Homo sapiens
review
Reference: Mrak RE and Griffin WS(2004) Trisomy 21 and the brain J. Neuropathol. Exp. Neurol. 63: 679-685 [PMID: 15290893]

Interaction Information:

Comment IL-1 upregulates betaAPP and S100B expression and drives numerous neurodegenerative and self-amplifying cascades that support a neuroinflammatory component in the pathogenesis of sporadic and Down syndrome-related Alzheimer disease.
Formal Description
Interaction-ID: 7760

gene/protein

IL1B

affects_activity of

Drugbank entries Show/Hide entries for IL1B