General Information:

Id: 1,169
Diseases: Alzheimer disease - [OMIM]
Down syndrome - [OMIM]
Homo sapiens
review
Reference: Mrak RE and Griffin WS(2004) Trisomy 21 and the brain J. Neuropathol. Exp. Neurol. 63: 679-685 [PMID: 15290893]

Interaction Information:

Comment In adults with Down syndrome, neuronal loss is dramatic and neurofibrillary and neuritic Abeta plaque pathologies are consistent with Alzheimer disease.
Formal Description
Interaction-ID: 7724

disease

Down syndrome

increases_activity of

Comment S100B is overexpressed throughout life in Down patients.
Formal Description
Interaction-ID: 7733

disease

Down syndrome

increases_expression of

gene/protein

S100B

in Down patients; throughout life
Drugbank entries Show/Hide entries for S100B
Comment S100B overexpression correlates with Alzheimer pathology in post-adolescent Down syndrome patients and has been implicated in Abeta plaque pathogenesis.
Formal Description
Interaction-ID: 7738

gene/protein

S100B

increases_activity of

in post-adolescent Down syndrome patients
Drugbank entries Show/Hide entries for S100B
Comment Interleukin-1 (IL-1) is a non-chromosome-21-based cytokine that is also overexpressed throughout life in Down syndrome.
Formal Description
Interaction-ID: 7756

disease

Down syndrome

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment IL-1 upregulates betaAPP and S100B expression and drives numerous neurodegenerative and self-amplifying cascades that support a neuroinflammatory component in the pathogenesis of sporadic and Down syndrome-related Alzheimer disease.
Formal Description
Interaction-ID: 7757

gene/protein

IL1B

increases_expression of

gene/protein

S100B

Drugbank entries Show/Hide entries for IL1B or S100B
Comment IL-1 upregulates betaAPP and S100B expression and drives numerous neurodegenerative and self-amplifying cascades that support a neuroinflammatory component in the pathogenesis of sporadic and Down syndrome-related Alzheimer disease.
Formal Description
Interaction-ID: 7758

gene/protein

IL1B

increases_expression of

gene/protein

APP

Drugbank entries Show/Hide entries for IL1B or APP
Comment IL-1 upregulates betaAPP and S100B expression and drives numerous neurodegenerative and self-amplifying cascades that support a neuroinflammatory component in the pathogenesis of sporadic and Down syndrome-related Alzheimer disease.
Formal Description
Interaction-ID: 7760

gene/protein

IL1B

affects_activity of

Drugbank entries Show/Hide entries for IL1B
Comment S100B overexpression correlates with Alzheimer pathology in post-adolescent Down syndrome patients and has been implicated in Abeta plaque pathogenesis.
Formal Description
Interaction-ID: 77901

increases_expression of

gene/protein

S100B

in post-adolescent Down syndrome patients
Drugbank entries Show/Hide entries for S100B