General Information:

Id: 11,676 (click here to show other Interactions for entry)
Diseases: Immunological
SARS-CoV infection
Homo sapiens
HEK293T cells
article
Reference: Heurich A et al.(2014) TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein J. Virol. 88: 1293-1307 [PMID: 24227843]

Interaction Information:

Comment ADAM17, the ACE2 sheddase, requires arginine and lysine residues within ACE2 amino acids 652 to 659 for receptor cleavage and competes with TMPRSS2 for ACE2 processing.
Formal Description
Interaction-ID: 117211

gene/protein

ADAM17

decreases_quantity of

gene/protein

ACE2

via proteolytic processing
Drugbank entries Show/Hide entries for ADAM17 or ACE2