General Information:

Id: 11,676 (click here to show other Interactions for entry)
Diseases: Immunological
SARS-CoV infection
Homo sapiens
HEK293T cells
article
Reference: Heurich A et al.(2014) TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein J. Virol. 88: 1293-1307 [PMID: 24227843]

Interaction Information:

Comment TMPRSS2, HAT, and hepsin not only cleave and activate the spike protein (S) of SARS-CoV, in addition, they cleave the SARS-CoV receptor ACE2. ACE2 processing is required for augmentation of SARS-S-driven entry. Arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for ACE2 cleavage by TMPRSS2 and HAT. This indicates that TMPRSS2 facilitates SARS-CoV infection via two independent mechanisms, cleavage of ACE2, which might promote viral uptake, and cleavage of SARS-S, which activates the S protein for membrane fusion.
Formal Description
Interaction-ID: 116055

gene/protein

TMPRSS2

affects_activity of

gene/protein

ACE2

via proteolytic processing to improve SARS-S-driven transduction
Drugbank entries Show/Hide entries for ACE2