General Information:

Id: 11,676 (click here to show other Interactions for entry)
Diseases: Immunological
SARS-CoV infection
Homo sapiens
HEK293T cells
article
Reference: Heurich A et al.(2014) TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein J. Virol. 88: 1293-1307 [PMID: 24227843]

Interaction Information:

Comment TMPRSS2, HAT, and hepsin not only cleave and activate the spike protein (S) of SARS-CoV, in addition, they cleave the SARS-CoV receptor ACE2. ACE2 processing is required for augmentation of SARS-S-driven entry. Arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for ACE2 cleavage by TMPRSS2 and HAT. This indicates that TMPRSS2 facilitates SARS-CoV infection via two independent mechanisms, cleavage of ACE2, which might promote viral uptake, and cleavage of SARS-S, which activates the S protein for membrane fusion.
Formal Description
Interaction-ID: 116055

gene/protein

TMPRSS2

affects_activity of

gene/protein

ACE2

via proteolytic processing to improve SARS-S-driven transduction
Drugbank entries Show/Hide entries for ACE2
Comment ADAM17, the ACE2 sheddase, requires arginine and lysine residues within ACE2 amino acids 652 to 659 for receptor cleavage and competes with TMPRSS2 for ACE2 processing.
Formal Description
Interaction-ID: 117211

gene/protein

ADAM17

decreases_quantity of

gene/protein

ACE2

via proteolytic processing
Drugbank entries Show/Hide entries for ADAM17 or ACE2
Comment ADAM17, the ACE2 sheddase, requires arginine and lysine residues within ACE2 amino acids 652 to 659 for receptor cleavage and competes with TMPRSS2 for ACE2 processing.
Formal Description
Interaction-ID: 117212

gene/protein

ADAM17

affects_activity of

gene/protein

TMPRSS2

Drugbank entries Show/Hide entries for ADAM17
Comment ADAM17, the ACE2 sheddase, requires arginine and lysine residues within ACE2 amino acids 652 to 659 for receptor cleavage and competes with TMPRSS2 for ACE2 processing.
Formal Description
Interaction-ID: 117762

gene/protein

ADAM17

increases_quantity of

gene/protein

ACE2, soluble

Drugbank entries Show/Hide entries for ADAM17
Comment ADAM17, the ACE2 sheddase, requires arginine and lysine residues within ACE2 amino acids 652 to 659 for receptor cleavage and competes with TMPRSS2 for ACE2 processing.
Formal Description
Interaction-ID: 119246

gene/protein

ACE2

increases_quantity of

gene/protein

ACE2, soluble

via proteolytic activity of ADAM17
Drugbank entries Show/Hide entries for ACE2