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Alzheimer disease
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Diabetes mellitus, type II
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	Field	Term

General Information:

Id:	1,162 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Organism Model:	LIKK mouse: mouse selectively expressing constitutively active IKK-beta in hepatocytes; LISR mouse: mouse selectively expressing the I-kappa-B-alpha superrepressor in liver
Publication type:	article
Reference:	Cai D et al.(2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat Med 11: 183-190 [PMID: 15685173]

Interaction Information:

Comment	Message levels of NF-kappaB targets were elevated by HFD. mRNAs encoding IL-6, Il-1beta and TNF-alpha were increased by 6.1-, 3.5- and 2.6-fold, respectively. Each of the encoded cytokines has been associated previously with the development of insulin resistance.
Formal Description Interaction-ID: 7650	environment high-fat diet increases_expression of gene/protein IL6
Drugbank entries	Show/Hide entries for IL6
Drugbank DB01404	Ginseng antagonist IL6
Drugbank DB01404	Ginseng antagonist IL6

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