General Information:
Id: | 1,162 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
Mus musculus | |
LIKK mouse: mouse selectively expressing constitutively active IKK-beta in hepatocytes; LISR mouse: mouse selectively expressing the I-kappa-B-alpha superrepressor in liver | |
article | |
Reference: | Cai D et al.(2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat Med 11: 183-190 [PMID: 15685173] |
Interaction Information:
Comment | Message levels of NF-kappaB targets were elevated by HFD. mRNAs encoding IL-6, Il-1beta and TNF-alpha were increased by 6.1-, 3.5- and 2.6-fold, respectively. Each of the encoded cytokines has been associated previously with the development of insulin resistance. |
Formal Description Interaction-ID: 7650 |
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Drugbank entries | Show/Hide entries for IL6 |