General Information:

Id: 1,158 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Tuncman G et al.(2006) Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance Proc. Natl. Acad. Sci. U.S.A. 103 [PMID: 16818881]

Interaction Information:

Comment To address the role of the JNK2 isoform in metabolic homeostasis, Jnk1(-/-) and Jnk2(-/-) mice were intercrossed and body weight and glucose metabolism in the resulting mutant allele combinations was examined. Among all of the viable genotypes examined, only reduced body weight and increased insulin sensitivity in Jnk1(-/-) and Jnk1(+/-)Jnk2(-/-) mice was observed. These two groups of mice also exhibited reduced total JNK activity and cytokine expression in liver tissue compared with all other genotypes examined. The cytokines included the mRNAs for: TNF-alpha, IL-6, IL-12, monocyte chemotactic protein 1 (MCP-1), and macrophage migration inhibitory factor (MIF).
Formal Description
Interaction-ID: 7596

gene/protein

MAPK8

affects_expression of

gene/protein

IL6

in liver
Drugbank entries Show/Hide entries for MAPK8 or IL6