General Information:

Id: 1,150 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0003292 RAW-264.7 cell
article
Reference: Matsuzawa A et al.(2005) ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat. Immunol. 6: 587-592 [PMID: 15864310]

Interaction Information:

Comment ASK1 is selectively required for TLR4-induced cytokine production (e.g. IL-6) via p38.
Formal Description
Interaction-ID: 7513

gene/protein

TLR4

increases_quantity of

gene/protein

IL6

after induction with LPS and in the presence of ASK1
Drugbank entries Show/Hide entries for TLR4 or IL6