General Information:

Id: 1,150 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0003292 RAW-264.7 cell
article
Reference: Matsuzawa A et al.(2005) ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat. Immunol. 6: 587-592 [PMID: 15864310]

Interaction Information:

Comment LPS-induced production of IL-6, tumor necrosis factor (TNF), nitric oxide and IL-1beta was diminished in ASK1-deficient splenocytes, indicating that ASK1 is required for LPS-induced cytokine production.
Formal Description
Interaction-ID: 7507

gene/protein

MAP3K5

increases_quantity of

gene/protein

IL6

after induction with LPS
Drugbank entries Show/Hide entries for IL6