General Information:

Id: 114
Diseases: Amyotrophic lateral sclerosis
Mus musculus
E12.5 mouse embryos
BTO:0001279 spinal cord
article
Reference: Nishitoh H et al.(2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev. 22: 1451-1464 [PMID: 18519638]

Interaction Information:

Comment Expression of neither SOD1wt nor SOD1G93A affected the number of glial cells. SOD1mut was selectively toxic to motor neurons and not glial cells.
Formal Description
Interaction-ID: 387

gene/protein mutant

SOD1-p.G93A

NOT affects_quantity of

tissue/cell line

glia

Comment SOD1G93A was selectively toxic to motor neurons and not glial cells.
Formal Description
Interaction-ID: 390

gene/protein mutant

SOD1-p.G93A

decreases_quantity of

tissue/cell line

motoneuron

Comment SOD1G93A was selectively toxic to motor neurons and not glial cells.
Formal Description
Interaction-ID: 85862

gene/protein mutant

SOD1-p.G93A

increases_activity of

phenotype

motor neuron degeneration