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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	1,145 (click here to show other Interactions for entry)
Diseases:	Parkinson disease
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000078 microglia; BTO:0000078 microglia; BTO:0000078 THP-1 cell
Publication type:	article
Reference:	Klegeris A et al.(2008) Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia Neurobiol. Aging 29: 739-752 [PMID: 17166628]

Interaction Information:

Comment	Alpha-synuclein induces inflammation in human microglial and human THP-1 cells.
Formal Description Interaction-ID: 7459	gene/protein SNCA increases_activity of process inflammatory response

Comment	Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description Interaction-ID: 7464	gene/protein mutant SNCA-p.A30P increases_activity of process inflammatory response more efficiently than wildtype SNCA

Comment	Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description Interaction-ID: 7465	gene/protein mutant SNCA-p.E46K increases_activity of process inflammatory response more efficiently than wildtype SNCA

Comment	Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description Interaction-ID: 7466	gene/protein mutant SNCA-p.A53T increases_activity of process inflammatory response more efficiently than wildtype SNCA

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