General Information:

Id: 1,145 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000078 microglia; BTO:0000078 microglia; BTO:0000078 THP-1 cell
article
Reference: Klegeris A et al.(2008) Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia Neurobiol. Aging 29: 739-752 [PMID: 17166628]

Interaction Information:

Comment Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description
Interaction-ID: 7464

gene/protein mutant

SNCA-p.A30P

increases_activity of

more efficiently than wildtype SNCA