General Information:

Id: 1,145
Diseases: Parkinson disease
Homo sapiens
BTO:0000078 microglia; BTO:0000078 microglia; BTO:0000078 THP-1 cell
article
Reference: Klegeris A et al.(2008) Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia Neurobiol. Aging 29: 739-752 [PMID: 17166628]

Interaction Information:

Comment Alpha-synuclein induces inflammation in human microglial and human THP-1 cells.
Formal Description
Interaction-ID: 7457

gene/protein

SNCA

increases_activity of

Comment Alpha-synuclein induces inflammation in human microglial and human THP-1 cells.
Formal Description
Interaction-ID: 7459

gene/protein

SNCA

increases_activity of

Comment Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description
Interaction-ID: 7460

gene/protein mutant

SNCA-p.A30P

increases_activity of

more efficiently than wildtype SNCA
Comment Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description
Interaction-ID: 7462

gene/protein mutant

SNCA-p.E46K

increases_activity of

more efficiently than wildtype SNCA
Comment Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description
Interaction-ID: 7463

gene/protein mutant

SNCA-p.A53T

increases_activity of

more efficiently than wildtype SNCA
Comment Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description
Interaction-ID: 7464

gene/protein mutant

SNCA-p.A30P

increases_activity of

more efficiently than wildtype SNCA
Comment Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description
Interaction-ID: 7465

gene/protein mutant

SNCA-p.E46K

increases_activity of

more efficiently than wildtype SNCA
Comment Disease-causing mutations of alpha-synuclein, A30P, E46K, A53T, induce inflammation more efficiently than wildtype SNCA.
Formal Description
Interaction-ID: 7466

gene/protein mutant

SNCA-p.A53T

increases_activity of

more efficiently than wildtype SNCA
Comment Overexpression of alpha-synuclein increases levels of inflammatory markers like IL-1beta and TNFalpha, secreated from THP-1 cells.
Formal Description
Interaction-ID: 7471

gene/protein

SNCA

increases_quantity of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment Overexpression of alpha-synuclein increases levels of inflammatory markers like IL-1beta and TNFalpha, secreated from THP-1 cells.
Formal Description
Interaction-ID: 7472

gene/protein

SNCA

increases_quantity of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment IFNgamma induced increase in Retinoblastoma protein or nucleophosmin phosphorylation was reversed in the presence of alpha-synuclein.
Formal Description
Interaction-ID: 7474

gene/protein

SNCA

decreases_phosphorylation of

gene/protein

RB1

after IFNgamma-induced increase in phosphorylation
Drugbank entries Show/Hide entries for RB1
Comment IFNgamma induced increase in Retinoblastoma protein or nucleophosmin phosphorylation was reversed in the presence of alpha-synuclein.
Formal Description
Interaction-ID: 7475

gene/protein

SNCA

decreases_phosphorylation of

gene/protein

NPM1

after IFNgamma-induced increase in phosphorylation
Comment Alpha-synuclein caused increased phosphorylation of the three major mitogen-activated protein (MAP) kinase pathways: p38 MAP kinase, extracellular regulated protein-serine kinase (ERK)1/2 and c-Jun-N-terminal kinase (JNK).
Formal Description
Interaction-ID: 7476

gene/protein

SNCA

increases_phosphorylation of

gene/protein

p38 MAPK

Comment Alpha-synuclein caused increased phosphorylation of the three major mitogen-activated protein (MAP) kinase pathways: p38 MAP kinase, extracellular regulated protein-serine kinase (ERK)1/2 and c-Jun-N-terminal kinase (JNK).
Formal Description
Interaction-ID: 7478

gene/protein

SNCA

increases_phosphorylation of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8
Comment Alpha-synuclein caused increased phosphorylation of the three major mitogen-activated protein (MAP) kinase pathways: p38 MAP kinase, extracellular regulated protein-serine kinase (ERK)1/2 and c-Jun-N-terminal kinase (JNK).
Formal Description
Interaction-ID: 7479

gene/protein

SNCA

increases_phosphorylation of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for MAPK3
Comment Alpha-synuclein caused increased phosphorylation of the three major mitogen-activated protein (MAP) kinase pathways: p38 MAP kinase, extracellular regulated protein-serine kinase (ERK)1/2 and c-Jun-N-terminal kinase (JNK).
Formal Description
Interaction-ID: 7480

gene/protein

SNCA

increases_phosphorylation of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for MAPK1
Comment Alpha-synuclein caused increased phosphorylation of the three major mitogen-activated protein (MAP) kinase pathways: p38 MAP kinase, extracellular regulated protein-serine kinase (ERK)1/2 and c-Jun-N-terminal kinase (JNK).
Formal Description
Interaction-ID: 7481

gene/protein

SNCA

increases_activity of

Comment Alpha-synuclein caused increased phosphorylation of the three major mitogen-activated protein (MAP) kinase pathways: p38 MAP kinase, extracellular regulated protein-serine kinase (ERK)1/2 and c-Jun-N-terminal kinase (JNK).
Formal Description
Interaction-ID: 7482

gene/protein

SNCA

increases_activity of

Comment Alpha-synuclein caused increased phosphorylation of the three major mitogen-activated protein (MAP) kinase pathways: p38 MAP kinase, extracellular regulated protein-serine kinase (ERK)1/2 and c-Jun-N-terminal kinase (JNK).
Formal Description
Interaction-ID: 7483

gene/protein

SNCA

increases_activity of

process

JNK cascade

Comment IFNgamma induced increase in Retinoblastoma protein or nucleophosmin phosphorylation was reversed in the presence of alpha-synuclein.
Formal Description
Interaction-ID: 11479

gene/protein

IFNG

increases_phosphorylation of

gene/protein

RB1

Drugbank entries Show/Hide entries for IFNG or RB1
Comment IFNgamma induced increase in Retinoblastoma protein or nucleophosmin phosphorylation was reversed in the presence of alpha-synuclein.
Formal Description
Interaction-ID: 11480

gene/protein

IFNG

increases_phosphorylation of

gene/protein

NPM1

Drugbank entries Show/Hide entries for IFNG