General Information:

Id: 113
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0001760 myotubes (L6)
article
Reference: Alessi DR et al.(1996) Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15: 6541-6551 [PMID: 8978681]

Interaction Information:

Comment Insulin activated endogenous protein kinase Ba (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes.
Formal Description
Interaction-ID: 385

complex/PPI

Insulin

increases_activity of

gene/protein

AKT1

by phosphorylation
Drugbank entries Show/Hide entries for AKT1
Comment The activation of AKT1 was accompanied by its phosphorylation at Thr3O8 and Ser473 and, like activation, phosphorylation of both of these residues was prevented by the phosphatidylinositol 3-kinase inhibitor wortmannin.
Formal Description
Interaction-ID: 395

complex/PPI

Insulin

affects_phosphorylation of

gene/protein

AKT1

at Thr308 and Ser473
Drugbank entries Show/Hide entries for AKT1
Comment Wortmannin is a phosphatidylinositol 3-kinase inhibitor.
Formal Description
Interaction-ID: 396

drug/chemical compound

Wortmannin

decreases_phosphorylation of

gene/protein

AKT1

at Thr308 and Ser473
Drugbank entries Show/Hide entries for AKT1