CIDeRGeneral Information:
| Id: | 1,139 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| article | |
| Reference: | Baumann CA et al.(2000) CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407: 202-207 [PMID: 11001060] |
Interaction Information:
| Comment | Insulin stimulated the translocation of GLUT4-EGFP to the plasma membrane in cells transfected with CAP, as detected by the presence of a continuous rim of cell-surface EGFP fluorescence. In contrast, expression of CAP-delta-SH3 markedly inhibited GLUT4-EGFP translocation to the cell surface in response to insulin. |
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Formal Description Interaction-ID: 7458 |
|
| Comment | Localization of the Cbl-CAP complex to lipid raft subdomains of the plasma membrane generates a pathway that is crucial in the regulation of glucose uptake. |
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Formal Description Interaction-ID: 7469 |
complex/PPI CAP-CBL complex affects_activity of process |