General Information:

Id: 1,137 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000078 microglia
article
Reference: Lee EJ et al.(2010) Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1 J. Immunol. 185: 615-623 [PMID: 20511551]

Interaction Information:

Comment Alpha-synuclein was found to significantly induce proinflammatory cytokines, like IL-1beta and TNFalpha and to increase the production of NO and ROS in a concentration-dependent manner.
Formal Description
Interaction-ID: 7394

gene/protein

SNCA

increases_quantity of

drug/chemical compound

NO

in microglia
Comment Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description
Interaction-ID: 7402

gene/protein

MMP3

affects_quantity of

drug/chemical compound

NO

after stimulation with alpha-synuclein
Drugbank entries Show/Hide entries for MMP3
Comment Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description
Interaction-ID: 7407

gene/protein

MMP8

affects_quantity of

drug/chemical compound

NO

after stimulation with alpha-synuclein
Drugbank entries Show/Hide entries for MMP8
Comment Inhibition of MMP-3, -8, or -9 with NNGH, M8I or M9I, suppresses the production of NO, proinflammatory cytokines, and ROS in primary microglia.
Formal Description
Interaction-ID: 7411

gene/protein

MMP9

affects_quantity of

drug/chemical compound

NO

after stimulation with alpha-synuclein