General Information:

Id: 1,137 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000078 microglia
Reference: Lee EJ et al.(2010) Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1 J. Immunol. 185: 615-623 [PMID: 20511551]

Interaction Information:

Comment Alpha-synuclein was found to significantly induce proinflammatory cytokines, like IL-1beta and TNFalpha and to increase the production of NO and ROS in a concentration-dependent manner.
Formal Description
Interaction-ID: 7395



increases_quantity of

drug/chemical compound

Reactive oxygen species

in microglia