General Information:

Id: 1,126 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0001311 corpus striatum; BTO:0000143 substantia nigra
article
Reference: Chung CY et al.(2009) Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy J. Neurosci. 29: 3365-3373 [PMID: 19295143]

Interaction Information:

Comment After transfection with A53T alpha-synuclein a neuroinflammatory response was observed at 8 weeks in the striatum, but not in the SN, demonstrated by increased levels of Iba-1, activated microglia and increased levels of proinflammatory cytokines, including IL-1beta, IFN-gamma and TNFalpha.
Formal Description
Interaction-ID: 7310

gene/protein mutant

SNCA-p.A53T

increases_activity of

in striatum, but not in substantia nigra