General Information:

Id: 1,125 (click here to show other Interactions for entry)
Diseases: Epilepsy
Mammalia
review
Reference: Rao RS et al.(2009) Role of different cytokines and seizure susceptibility: a new dimension towards epilepsy research. Indian J. Exp. Biol. 47: 625-634 [PMID: 19775068]

Interaction Information:

Comment Exogenous application of inflammatory cytokine L1B prolonged seizures enhancing glutamatergic neurotransmission. IL-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family kinases.
Formal Description
Interaction-ID: 7270

complex/PPI

NMDA receptor complex

increases_quantity of

drug/chemical compound

Ca2+