General Information:

Id: 1,125
Diseases: Epilepsy
Mammalia
review
Reference: Rao RS et al.(2009) Role of different cytokines and seizure susceptibility: a new dimension towards epilepsy research. Indian J. Exp. Biol. 47: 625-634 [PMID: 19775068]

Interaction Information:

Comment The proinflammatory signals IL-1beta and TNF-alpha contents were increased in the whole brain after the rats were kindled by electrical stimulation.
Formal Description
Interaction-ID: 7259

environment

electrical stimulation

increases_activity of

Comment The proinflammatory signals IL-1beta and TNF-alpha contents were increased in the whole brain after the rats were kindled by electrical stimulation.
Formal Description
Interaction-ID: 7260

increases_quantity of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment The proinflammatory signals IL-1beta and TNF-alpha contents were increased in the whole brain after the rats were kindled by electrical stimulation.
Formal Description
Interaction-ID: 7261

increases_quantity of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment The inflammatory cytokines IL1 alpha and IL1beta bind to the same receptor.
Formal Description
Interaction-ID: 7262

gene/protein

IL1B

interacts (colocalizes) with

gene/protein

IL1R1

Drugbank entries Show/Hide entries for IL1B or IL1R1
Comment The inflammatory cytokines IL1 alpha and IL1beta bind to the same receptor.
Formal Description
Interaction-ID: 7263

gene/protein

IL1A

interacts (colocalizes) with

gene/protein

IL1R1

Drugbank entries Show/Hide entries for IL1R1
Comment IL-1Ralpha binds to IL1R1 and prevents binding of inflammatory cytokines, and had a powerful anticonvulsant action in various modes of limbic seizures.
Formal Description
Interaction-ID: 7264

gene/protein

IL1RN

interacts (colocalizes) with

gene/protein

IL1R1

Drugbank entries Show/Hide entries for IL1R1
Comment IL-1Ralpha binds to IL1R1 and prevents binding of inflammatory cytokines, and had a powerful anticonvulsant action in various modes of limbic seizures.
Formal Description
Interaction-ID: 7265

gene/protein

IL1RN

decreases_activity of

complex/PPI

IL1B-IL1R1 complex

Comment IL-1Ralpha binds to IL1R1 and prevents binding of inflammatory cytokines, and had a powerful anticonvulsant action in various modes of limbic seizures.
Formal Description
Interaction-ID: 7266

gene/protein

IL1RN

decreases_activity of

complex/PPI

IL1A-IL1R1 complex

Comment IL-1Ralpha binds to IL1R1 and prevents binding of inflammatory cytokines, and had a powerful anticonvulsant action in various modes of limbic seizures.
Formal Description
Interaction-ID: 7267

gene/protein

IL1RN

decreases_activity of

Comment Exogenous application of inflammatory cytokine IL1B prolonged seizures enhancing glutamatergic neurotransmission. IL-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family kinases.
Formal Description
Interaction-ID: 7268

gene/protein

IL1B

increases_activity of

gene/protein

SRC

Drugbank entries Show/Hide entries for IL1B or SRC
Comment Exogenous application of inflammatory cytokine IL1B prolonged seizures enhancing glutamatergic neurotransmission. IL-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family kinases.
Formal Description
Interaction-ID: 7269

gene/protein

SRC

increases_activity of

complex/PPI

NMDA receptor complex

Drugbank entries Show/Hide entries for SRC
Comment Exogenous application of inflammatory cytokine L1B prolonged seizures enhancing glutamatergic neurotransmission. IL-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family kinases.
Formal Description
Interaction-ID: 7270

complex/PPI

NMDA receptor complex

increases_quantity of

drug/chemical compound

Ca2+

Comment Exogenous application of Iinflammatory cytokine L1B prolonged seizures enhancing glutamatergic neurotransmission. IL-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family kinases.
Formal Description
Interaction-ID: 7271

drug/chemical compound

Ca2+

increases_activity of