General Information:

Id: 1,124 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mammalia
BTO:0000078 microglia; BTO:0000099 astrocyte; BTO:0003350 BV-2 cell
article
Reference: Saijo K et al.(2009) A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death Cell 137: 47-59 [PMID: 19345186]

Interaction Information:

Comment A30P expression alone caused weak inflammation in the SN, whereas reduction of Nurr1 expression in the context of A30P expression resulted in a dramatic increase, indicating that Nurr1 limits inflammatory responses in the CNS.
Formal Description
Interaction-ID: 7236

gene/protein mutant

SNCA-p.A30P

increases_activity of

in substantia nigra
Comment A30P expression alone caused weak inflammation in the SN, whereas reduction of Nurr1 expression in the context of A30P expression resulted in a dramatic increase, indicating that Nurr1 limits inflammatory responses in the CNS.
Formal Description
Interaction-ID: 7237

gene/protein

NR4A2

decreases_activity of

in substantia nigra; via recruiting the CoREST-CtBP complex
Comment Microglia are the initial responders to LPS-mediated inflammation and that astrocytes amplify the production of neurotoxic factors after the microglial activation.
Formal Description
Interaction-ID: 7246

drug/chemical compound

Lipopolysaccharide

increases_activity of

primarily in microglia cells
Comment Nurr1 interacts with NF-kappaB-p65, a transcription factor involved in inflammation. The interaction was significantly enhanced by LPS treatment.
Formal Description
Interaction-ID: 7253

gene/protein

RELA

affects_activity of

via NF-kappaB signaling
Drugbank entries Show/Hide entries for RELA