General Information:

Id: 1,124 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mammalia
BTO:0000078 microglia; BTO:0000099 astrocyte; BTO:0003350 BV-2 cell
article
Reference: Saijo K et al.(2009) A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death Cell 137: 47-59 [PMID: 19345186]

Interaction Information:

Comment Microglia are the initial responders to LPS-mediated inflammation and that astrocytes amplify the production of neurotoxic factors after the microglial activation.
Formal Description
Interaction-ID: 7246

drug/chemical compound

Lipopolysaccharide

increases_activity of

primarily in microglia cells