General Information:

Id: 1,123
Diseases: Parkinson disease
Mammalia
article/cited
Reference: Saijo K et al.(2009) A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death Cell 137: 47-59 [PMID: 19345186]

Interaction Information:

Comment Nurr1, an orphan nuclear receptor, plays an essential role in the generation and maintenance of dopaminergic neurons in the brain. (cited information)
Formal Description
Interaction-ID: 7215

gene/protein

NR4A2

affects_quantity of

tissue/cell line

dopaminergic neuron

Comment Mutations in Nurr1 are associated with familial Parkinsons disease, but the underlying basis for this relationship has not been established. (cited information)
Formal Description
Interaction-ID: 7216

gene/protein

NR4A2

increases_activity of

disease

Parkinson disease

Comment Nurr1 mRNA is induced by inflammatory stimuli, including LPS, in macrophages. (cited information)
Formal Description
Interaction-ID: 7217

increases_expression of

gene/protein

NR4A2

in macrophages
Comment Nurr1 mRNA is induced by inflammatory stimuli, including LPS, in macrophages. (cited information)
Formal Description
Interaction-ID: 7218

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

NR4A2

Comment Nurr1 mRNA is induced by inflammatory stimuli, including LPS, in macrophages. (cited information)
Formal Description
Interaction-ID: 7231

drug/chemical compound

Lipopolysaccharide

increases_activity of

Comment Nurr1 interacts with the protein inhibitor of activated STAT (PIAS) 4, which is a SUMO E3 ligase. (cited information)
Formal Description
Interaction-ID: 7249

gene/protein

NR4A2

interacts (colocalizes) with

gene/protein

PIAS4