General Information:

Id: 1,122 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0001311 corpus striatum
article
Reference: Mogi M et al.(1994) Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180: 147-150 [PMID: 7700568]

Interaction Information:

Comment The concentrations of various pro-inflammatory cytokines, like IL-1 beta, IL-6, EGF, and TGF-alpha in the dopaminergic, striatal regions were significantly higher in parkinsonian patients than those in controls, whereas those in the cerebral cortex did not show significant differences between parkinsonian and control subjects. Since these cytokines and growth factors may play important roles as neurotrophic factors in the brain, they may be produced as compensatory responses.
Formal Description
Interaction-ID: 7212

disease

Parkinson disease

increases_quantity of

gene/protein

IL6

in striatum but not in cerebral cortex
Drugbank entries Show/Hide entries for IL6