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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	111 (click here to show other Interactions for entry)
Diseases:	Amyotrophic lateral sclerosis
Organism:	Mus musculus
Tissue/Cell line:	BTO:0001279 spinal cord
Publication type:	article
Reference:	Nishitoh H et al.(2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev. 22: 1451-1464 [PMID: 18519638]

Interaction Information:

Comment	The expression of SOD1(G93A) in neuronal tissues and liver was higher than in other organs and the interaction of Derlin-1 with SOD1mut, but not SOD1wt, was observed specifically in these tissues: liver, cerebral cortex, cerebellum, medulla, and spinal cord.
Formal Description Interaction-ID: 377	gene/protein mutant SOD1-p.G93A interacts (colocalizes) with gene/protein DERL1 in spinal cord

Comment	SOD1(G93A) exists mainly in the cytosol, and some fraction of SOD1mut attaches to the cytosolic surface of the ER.
Formal Description Interaction-ID: 379	gene/protein mutant SOD1-p.G93A is localized in cellular component cytoplasm mainly

Comment	SOD1(G93A) exists mainly in the cytosol, and some fraction of SOD1mut attaches to the cytosolic surface of the ER.
Formal Description Interaction-ID: 381	gene/protein mutant SOD1-p.G93A is localized in cellular component endoplasmic reticulum membrane partly

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