General Information:

Id: 1,119
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000601 hippocampus, BTO:0001355 temporal lobe
article
Reference: Lukiw WJ et al.(2008) An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells J. Biol. Chem. 283 [PMID: 18801740]

Interaction Information:

Comment NF-kappaB-sensitive miRNA-146a was up-regulated in brain of Alzheimer disease (AD) patients. The target of miRNA-146a CFH, a repressor of the immune response and inflammatory signaling, was down-regulated in the same brain regions of AD patients.
Formal Description
Interaction-ID: 7178

increases_expression of

ncRNA/miRNA

mir-146a

Comment NF-kappaB-sensitive miRNA-146a was up-regulated in brain of Alzheimer disease (AD) patients. The target of miRNA-146a CFH, a repressor of the immune response and inflammatory signaling, was down-regulated in the same brain regions of AD patients.
Formal Description
Interaction-ID: 7179

ncRNA/miRNA

mir-146a

decreases_expression of

gene/protein

CFH

Comment NF-kappaB-sensitive miRNA-146a was up-regulated in brain of Alzheimer disease (AD) patients. The target of miRNA-146a CFH, a repressor of the immune response and inflammatory signaling, was down-regulated in the same brain regions of AD patients.
Formal Description
Interaction-ID: 7180

gene/protein

CFH

decreases_activity of

Comment NF-kappaB-sensitive miRNA-146a was up-regulated in brain of Alzheimer disease (AD) patients. The target of miRNA-146a CFH, a repressor of the immune response and inflammatory signaling, was down-regulated in the same brain regions of AD patients.
Formal Description
Interaction-ID: 7181

gene/protein

CFH

decreases_activity of

process

immune response