General Information:

Id: 1,114
Diseases: Cardiovascular disease
Mammalia
article/cited
Reference: Zhang C et al.(2008) Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1. Biochim. Biophys. Acta 1783: 1517-1528 [PMID: 18439917]

Interaction Information:

Comment Adequate Prolyl-4-hydroxylase expression is essential for the formation of functional collagen in the arterial wall and pathogenesis of vascular diseases, e.g. atherosclerosis or aortic aneurysm. (cited information)
Formal Description
Interaction-ID: 7156

gene/protein

P4HA1

increases_activity of

Drugbank entries Show/Hide entries for P4HA1
Comment Adequate Prolyl-4-hydroxylase expression is essential for the formation of functional collagen in the arterial wall and pathogenesis of vascular diseases, e.g. atherosclerosis or aortic aneurysm. (cited information)
Formal Description
Interaction-ID: 7157

gene/protein

P4HA1

increases_activity of

process

angiogenesis

Drugbank entries Show/Hide entries for P4HA1
Comment Adequate Prolyl-4-hydroxylase expression is essential for the formation of functional collagen in the arterial wall and pathogenesis of vascular diseases, e.g. atherosclerosis or aortic aneurysm. (cited information)
Formal Description
Interaction-ID: 7158

increases_activity of

process

angiogenesis

Comment The extracellular matrix (ECM) of the vasculature is a major target of inflammatory cytokines, and TNFalpha regulates ECM metabolism by affecting collagen production. (cited information)
Formal Description
Interaction-ID: 7202

gene/protein

TNF

affects_activity of

Drugbank entries Show/Hide entries for TNF
Comment TNFalpha, one of the inflammatory cytokines, is one of the most potent ones implicated in the development of cardiovascular diseases. (cited information)
Formal Description
Interaction-ID: 7203

gene/protein

TNF

increases_activity of

Drugbank entries Show/Hide entries for TNF