General Information:

Id: 1,112 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
transgenic hAPP/TGFbeta1 mouse
article
Reference: Wyss-Coray T et al.(2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Nat. Med. 7: 612-618 [PMID: 11329064]

Interaction Information:

Comment The reduction of parenchymal plaques in hAPP/TGF-beta1 mice was associated with a strong activation of microglia and an increase in inflammatory mediators.
Formal Description
Interaction-ID: 7184

organism model

transgenic hAPP/TGFbeta1 mouse

increases_activity of

in transgenic hAPP/TGF-beta1 mice