General Information:

Id: 1,112
Diseases: Alzheimer disease - [OMIM]
Mus musculus
transgenic hAPP/TGFbeta1 mouse
article
Reference: Wyss-Coray T et al.(2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Nat. Med. 7: 612-618 [PMID: 11329064]

Interaction Information:

Comment Here we demonstrate that a modest increase in astroglial TGF-beta1 production in aged transgenic mice expressing the human beta-amyloid precursor protein (hAPP) results in a three-fold reduction in the number of parenchymal amyloid plaques, a 50% reduction in the overall Abeta load in the hippocampus and neocortex, and a decrease in the number of dystrophic neurites.
Formal Description
Interaction-ID: 7126

gene/protein

TGFB1

decreases_quantity of

in aged transgenic hAPP mice brain; if the astroglial TGF-beta1 production is increased
Drugbank entries Show/Hide entries for TGFB1
Comment In mice expressing hAPP and TGF-beta1, Abeta accumulated substantially in cerebral blood vessels, but not in parenchymal plaques.
Formal Description
Interaction-ID: 7127

organism model

transgenic hAPP/TGFbeta1 mouse

increases_quantity of

gene/protein

Amyloid beta peptide

in cerebral blood vessels; in transgenic hAPP/TGF-beta1 mice
Comment The reduction of parenchymal plaques in hAPP/TGF-beta1 mice was associated with a strong activation of microglia and an increase in inflammatory mediators.
Formal Description
Interaction-ID: 7182

organism model

transgenic hAPP/TGFbeta1 mouse

decreases_quantity of

in hippocampus; of transgenic hAPP/TGF-beta1 mice; associated with a strong activation of microglia and an increase in inflammatory mediators
Comment The reduction of parenchymal plaques in hAPP/TGF-beta1 mice was associated with a strong activation of microglia and an increase in inflammatory mediators.
Formal Description
Interaction-ID: 7183

organism model

transgenic hAPP/TGFbeta1 mouse

increases_activity of

in transgenic hAPP/TGF-beta1 mice
Comment The reduction of parenchymal plaques in hAPP/TGF-beta1 mice was associated with a strong activation of microglia and an increase in inflammatory mediators.
Formal Description
Interaction-ID: 7184

organism model

transgenic hAPP/TGFbeta1 mouse

increases_activity of

in transgenic hAPP/TGF-beta1 mice
Comment Here we demonstrate that a modest increase in astroglial TGF-beta1 production in aged transgenic mice expressing the human beta-amyloid precursor protein (hAPP) results in a three-fold reduction in the number of parenchymal amyloid plaques, a 50% reduction in the overall Abeta load in the hippocampus and neocortex, and a decrease in the number of dystrophic neurites.
Formal Description
Interaction-ID: 7185

organism model

transgenic hAPP mouse

decreases_quantity of

in aged transgenic hAPP mice brain; if the astroglial TGF-beta1 production is increased
Comment Here we demonstrate that a modest increase in astroglial TGF-beta1 production in aged transgenic mice expressing the human beta-amyloid precursor protein (hAPP) results in a three-fold reduction in the number of parenchymal amyloid plaques, a 50% reduction in the overall Abeta load in the hippocampus and neocortex, and a decrease in the number of dystrophic neurites.
Formal Description
Interaction-ID: 7186

organism model

transgenic hAPP mouse

decreases_quantity of

gene/protein

Amyloid beta peptide

in hippocampus and neocortex; of aged transgenic hAPP mice, if the astroglial TGF-beta1 production is increased
Comment Here we demonstrate that a modest increase in astroglial TGF-beta1 production in aged transgenic mice expressing the human beta-amyloid precursor protein (hAPP) results in a three-fold reduction in the number of parenchymal amyloid plaques, a 50% reduction in the overall Abeta load in the hippocampus and neocortex, and a decrease in the number of dystrophic neurites.
Formal Description
Interaction-ID: 7187

organism model

transgenic hAPP mouse

decreases_quantity of

phenotype

dystrophic neurites

in brain; of aged transgenic hAPP mice, if the astroglial TGF-beta1 production is increased
Comment In hAPP/TGF-beta1 mice TGF-beta1 increased microglial activation.
Formal Description
Interaction-ID: 7194

gene/protein

TGFB1

increases_activity of

in brain; of transgenic hAPP/TGF-beta1 mice
Drugbank entries Show/Hide entries for TGFB1
Comment CAA severity correlated positively with TGF-beta1 mRNA levels, as well as with Abeta immunoreactivity in the blood vessels. But some AD cases had essentially no cerebrovascular amyloidosis or cerebral amyloid angiopathy (CAA) with deposition of Abeta almost exclusively in plaques. In some AD cases with severe CAA often had relatively little amyloid deposition in plaques.
Formal Description
Interaction-ID: 7220

gene/protein

TGFB1

affects_activity of

CAA severity correlated positively with TGF-beta1 mRNA levels;
Drugbank entries Show/Hide entries for TGFB1