General Information:

Id: 1,111
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Wyss-Coray T et al.(2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Nat. Med. 7: 612-618 [PMID: 11329064]

Interaction Information:

Comment Abnormal accumulation of the amyloid-beta peptide (Abeta) in the brain appears crucial to pathogenesis in all forms of Alzheimer disease (AD).
Formal Description
Interaction-ID: 7124

gene/protein

Amyloid beta peptide

affects_activity of

Comment Transforming growth factor beta1 (TGF-beta1) is a key regulator of the brain's responses to injury and inflammation and has been implicated in Abeta deposition.
Formal Description
Interaction-ID: 7125

affects_activity of

gene/protein

TGFB1

in brain
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Comment Microglia are activated and a wide array of inflammatory proteins are expressed at elevated levels in the AD brain.
Formal Description
Interaction-ID: 7191

increases_activity of

Comment Cerebral TGF-beta1 levels are higher in AD cases than in nondemented controls, and TGF-beta1 immunoreactivity is increased in plaques and perivascular astrocytes.
Formal Description
Interaction-ID: 7198

increases_quantity of

gene/protein

TGFB1

Cerebral TGF-beta1 levels are higher in AD cases than in nondemented controls.
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Comment Cortical TGF-beta1 mRNA levels in AD cases correlate positively with the degree of CAA.
Formal Description
Interaction-ID: 7219

gene/protein

TGFB1

affects_activity of

Drugbank entries Show/Hide entries for TGFB1